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USC Lung Cancer Program

Lung Cancer Research

At the USC Lung Cancer Program, we are committed to finding the cures of tomorrow today and making lung cancer a disease of the past. Our clinicians and researchers continue to build on our legacy of leadership and innovation — achieving scientific breakthroughs in lung cancer prevention, detection and treatment strategies.

A researcher examines a test tube

Whether you have small cell lung cancer or non-small cell lung cancer, early stage lung cancer or stage 4 lung cancer, research can play a pivotal role in your treatment plan, giving you access to cutting-edge medications and treatment options. The strides made by our researchers can also make a profound difference in the lives of millions of people with lung cancer. By participating in a lung cancer trial, you too can make a vital contribution to the campaign to find new cancer treatments and, ultimately, a cure.

As an academic medical center, we are at the forefront of the most groundbreaking cancer trials available today. By choosing the USC Lung Cancer Program for your lung cancer care, you have access to the clinical trials that are driving the medical breakthroughs that will help us find tomorrow’s cures today. Together, we can make a difference and bring new hope to people with cancer.

Our offerings

  • Finding a cure
  • Improving detection, treatment, prevention
  • Lung cancer breakthroughs
  • Lung cancer clinical trials
  • National Cancer Institute (NCI) designation
  • Understanding lung cancer causes

What our National Cancer Institute designation means

In 1973, USC Norris Comprehensive Cancer Center was designated as one of the country’s original eight comprehensive cancer centers by the National Cancer Institute (NCI), the federal government’s principle agency for cancer research and training. As an NCI-designated cancer center, we anchor the country’s cancer research efforts, making scientific discoveries that are translated into new treatments for people with cancer. The collective work of NCI researchers has led to important medical advances that have increased the number of cancer survivors in the United States and worldwide.

USC Norris cancer research breakthroughs

Our clinician-scientists have been at the forefront of cancer research for more than 40 years, making historic breakthroughs that have changed the way we understand lung cancer and how it’s treated.

Participate in Lung Cancer Research

Below are open clinical trials at the USC Lung Cancer Program. You can learn more about whether a trial is a good match for you by clicking on it for more details.

Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)

PRIMARY OBJECTIVES: I. To centrally test resected non-small cell lung cancer (NSCLC) for genetic mutations to facilitate accrual to randomized adjuvant studies. II. To obtain clinically annotated tumor tissue ...

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A Phase 2 Study of Poziotinib in Patients With Non-Small Cell Lung Cancer (NSCLC), Locally Advanced or Metastatic, With EGFR or HER2 Exon 20 Insertion Mutation (ZENITH20)

The Screening period (Day -30 to Day -1) lasts up to approximately 30 days prior to Cycle 1, Day 1. Patients must meet all Inclusion/Exclusion Criteria to participate in ...

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A Phase III, Double-Blinded, Multicenter, Randomized Study Evaluating the Efficacy and Safety of Neoadjuvant Treatment With Atezolizumab or Placebo in Combination With Platinum-Based Chemotherapy in Patients With Resectable Stage II, IIIA, or Select IIIB Non−Small Cell Lung Cancer

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A Phase II Study of Epigenetic Therapy With Azacitidine and Entinostat With Concurrent Nivolumab in Subjects With Metastatic Non-Small Cell Lung Cancer.

Objective response rate to Nivolumab preceded by epigenetic priming. Response will be assessed by RECIST 1.1 criteria, baseline scans for this assessment will be the baseline scans done within ...

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A Randomized Phase III Trial for Surgically Resected Early Stage Non-small Cell Lung Cancer: Crizotinib Versus Observation for Patients With Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein

PRIMARY OBJECTIVES: I. To evaluate whether adjuvant therapy with crizotinib will result in improved overall survival (OS) for patients with stage IB >= 4 cm, II and IIIA, ALK-positive non- ...

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News and Stories

Meet Jason Ye, MD, Assistant Professor of Clinical Radiation Oncology

Dr. Ye is a radiation oncologist at USC Norris Comprehensive Cancer Center at Keck Medicine of USC. He specializes in a wide array of advanced radiation treatment techniques for people with lung, breast, brain and spine tumors. Here’s what you won’t find on his resume. He can’t wait to swim with manta rays in Kona.