Overview and Indications

Your genome is all the DNA contained in your cells. In most cells, the genome is packaged into two sets of chromosomes, composed of six billion individual DNA letters. Genomics is the study of the sequence of these letters in the DNA. Studying the cancer genome can unlock information regarding cancer risk or allow physicians to select the best treatment for individual patients.

In order to better understand how cancer risk can be passed on through our DNA, the National Cancer Institute initiated the program Genetic Associations and MEchanisms in ONcology, or GAME ON. The USC Norris Comprehensive Cancer Center is the only research center in the country to be leading two of the GAME ON studies – the ColoRectal Transdisciplinary Study (CORECT) and the Elucidating Loci Involved in Prostate Cancer Susceptibility study (ELLIPSE).

The science of studying cancer genomics is focused on improving the understanding of the genetic basis of cancer and cancer risk and many of the scientists involved are passionate about improving outcomes for patients. The long-term goal is to increase the knowledge about the genetic mechanisms of cancer in order to improve techniques for prevention and treatment.